In a recent study published in Nature Biotechnology, researchers developed a whole-genome sequencing (WGS) method that read four canonical deoxyribonucleic acid (DNA) bases, viz., adenine (A), ...

Commonly used sequencing approaches do not capture full information from both genetics and epigenetics. Some of these may involve separate, parallel workflows and sequencing to produce full ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

At least five groups have independently invented a new class of CRISPR gene editing tools called dual base editors. The systems combine the functions and components of two CRISPR base editors, which ...

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics-meticulously placed chemical tags that influence which genes are expressed in ...

Additions to DNA’s four-letter alphabet have been announced before, but the new letters don’t always fit comfortably into DNA’s double helix. Even slightly awkward letters can distort DNA’s overall ...

Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases. (Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base ...